A study published in the journal Cell Death & Disease shows that researchers have found out the protein responsible for head and neck cancer growth. Researchers at the Indian Institute of Science Education and Research (IISER), Bhopal have found that reduction in the amount of protein produced will eventually reduce the growth of such cell which is responsible for cancer growth. Research has found that proteins which are responsible for the growth are Kinase (p21-activated kinase 2 or PAK2).
PAK2 protein helps in cell proliferation, migration, invasion into the extracellular matrix, colony formation and even resistance to certain drugs. Reduction in the production of this protein leads to the less cell proliferation, migration, forming a colony and even lesser resistance in cancer drugs.
When PAK2 protein level was reduced, activation of signaling pathway was reduced. This pathway leads to the activation of genes which played important role in the cancer growth. Reduction in the amount of protein PAK2 leads to the reduction in activation level which affects the growth of the cancer gene C-Myc. C-Myc is the gene produced in the head and neck cancer cell growth.
Reduction in the cancer gene leads to the reduction in the production of metabolic enzyme PKM2. The PKM2 enzyme plays an important role as it speeds up the glucose conversion into lactate in cancer cells. Lactate provides energy and rapid cell division by providing new blocks for cell formation. So the reduction in the amount of protein PAK2 leads to the reduction in the ability of cell proliferation and migration.
The effect of PAK2 protein is well known but its cascading effect that is depletion of PAK2 results in the reduction of cancer gene and cancer-specific metabolism (PKM2) is new discovery regarding head and neck cancer.
Tags : #India#Madhya Pradesh#New Research